VerMidi XIX

VerMidi XIX - Friday Jan 8th 2016 - ENS Lyon


Marie Delattre's and my group are hosting the nineteenth VerMidi C. elegans Meeting at ENS Lyon in early 2016.
Registration is open on the meeting website.

  Muscle K2P BFP kockin

Nice!


Our latest TagBFP knockin in a muscle-expressed C. elegans K2P channel.

 We want to understand how cellular physiology is controled by basic molecular and cellular pathways regulating the biology of potassium-selective ion channels.

Two-pore domain potassium channels (K2P) play a central role in the control of cellular excitability and the regulation of the cell's electrical membrane potential. K2Ps have been widely conserved throughout evolution. They are polymodal ion channels that are subjected to extensive regulation by a diverse set of physical (pH, temperature, mechanical force) and biological signals (lipids, G-protein coupled receptor pathways). They are broadly expressed in excitable and non-excitable cells, and have in turn been implicated in a large spectrum of physiopathological processes, ranging from the regulation of neuronal excitability, respiratory and cardiac function to the control of cell volume, hormone secretion and cell proliferation. Recently, loss- and gain-of-function mutations in K2P channels have been directly linked to human pathologies (Birk Barel syndrome, familial migraine with aura, cardiac conduction disorder).

In contrast to many other ion channel families, comparatively little is known about the molecular and cellular processes that regulate different aspects of the cell biology of K2P channels. For instance we know only of very few factors that specifically regulate the expression, the activity and the localisation of K2P channels at the cell surface. Therefore the central question addressed by our team is: How is the number of active potassium leak channels present at the cell surface controlled in vivo?

To identify novel genes and conserved cellular processes that regulate the biology of K2P channels in vivo we take advantage of the powerful genetic tools available in the model nematode Caenorhabditis elegans. We use the full array of techniques available in C. elegans including genetics, live imaging, electrophysiology and state-of-the-art CRISPR/Cas9 genome engineering and next-generation DNA sequencing. These studies will provide new leads to understand the cellular pathways that control K2P function in other organisms.

  medaille-bronze

CNRS Bronze Medal


Thomas has received his Bronze medal during the official CNRS ceremony on December 4th, 2014

"La Médaille de bronze récompense le premier travail d'un chercheur, qui fait de lui un spécialiste de talent dans son domaine. Cette récompense représente un encouragement du CNRS à poursuivre des recherches bien engagées et déjà fécondes."

Press releases: CNRSUniversité de LyonFaculté des SciencesERC

  logo-ERC

Interested?


We are always looking for highly motivated Post-docs, Masters and PhD students to participate in our ERC Starting Grant-funded projects.
Please consult this page before applying.

 

Our Projects

We endeavor to understand how basic molecular and cellular pathways regulating the biology of potassium-selective ion channels control cellular physiology.

Lab Members

Funding & Support

Our research is funded by the European Research Council (ERC Stg 2013) and the Fondation Fyssen

Our Publications

A generally up-to-date list of our publications and meeting abstracts.

The Newsstand

An ever growing list of papers that stand out.

Tools

References to tools that might be of interest.

General & Travel Information

Directions

On this page you will find practical information about the lab (location, directions, etc.)

About Lyon

Welcome to Lyon. The capital of the Gauls (Lugdunum) is famous for its gastronomy and architecture.

Organisations & Funding

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